Live Geos: https://partners.subjectwell.com/publishers/geos_report/019b57fe-62ac-4353-87da-2115162b3dcf **ALL COPY AND CREATIVES MUST BE SUBMITTED TO [email protected] FOR APPROVAL PRIOR TO GO LIVE** Ages: 18 - 60 Study Description: This study is testing a new investigational medication in people with Relapsing-Forms of Multiple Sclerosis (RRMS and active SPMS) or Progressive Forms of Multiple Sclerosis (PPMS and inactive SPMS ), You will be asked to attend 4 initial visits to determine if you can enroll in the study and prepare you for the treatment. During one of the first treatment visits, you will complete a procedure called Leukapheresis during which your blood will be filtered through a machine to separate and collect white blood cells from your blood stream before returning the blood to your body. If you continue to meet eligibility for treatment, you will then receive chemotherapy treatments for 3 consecutive days (1 treatment per day). Once these procedures and treatments are complete, you will receive a single infusion of the investigational medication. For the first 2 weeks after treatment, you will be admitted to the hospital for observation. You will be required to stay at the hospital for the entire 2-week duration. You will need to remain near your assigned study site for an additional 2 weeks to complete the treatment period. Total study duration, including screening, is approximately 2.5 years with regular clinic visits, some of which will be conducted via telehealth. Study procedures and tests will include physical exams, blood and urine testing, various motor and cognitive function screens, and a MRI of the Brain/Cervical Spine. This study is recruiting nationwide. If you do not live near a study site, travel support will be provided to cover expenses associated with travel including accommodations for overnight and long-term stays. The doctor’s office conducting the study will be able to provide you with more information about the study and participation requirements. Qualifications: - Must be willing to stop taking current MS medications while participating - Cannot have had a heart attack in last six months - Must be willing to receive chemotherapy treatments while participating in this study

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