Ages: 18-70 Gender: Any Participants who qualify for the study will receive trial-related procedures and study medication at no cost and may be compensated up to $74 per visit for time and travel. Study Description: The purpose of the APATURA study is to see how effective an investigational medication is at helping to treat Systemic Lupus Erythematosus (SLE). You may be asked to attend 1 screening visit to determine if you are eligible to enroll in the study. If enrolled, you will receive the first dose of medication being tested in this study intravenously (through an IV), then the medication will be given as injections every 2 weeks for 6 months. Your total participation will last approximately 10 months and you will be asked to attend two study visits per month during the treatment period and once per month during the follow-up period. You will have the possibility of performing some of these visits remotely from your home, replacing physical office visits. During these visits, you will complete various diagnostic and laboratory tests. Participants who qualify for the study will receive trial-related procedures and study medication at no cost and may be compensated up to $74 per visit for time and travel. The doctor’s office conducting the study will be able to provide you with more information about the study requirements. Generalized Approved Copy in Creative Folder Qualifications: - Must be diagnosed with Systemic Lupus Erythematosus (SLE) for 6 months or longer - Cannot have a history of any of the following: Deep vein thrombosis, Pulmonary embolism, Heart attack, Stroke, or Transient ischemic attack (TIA) or mini-stroke - Must be taking medication to treat your lupus symptoms that could include: Oral Corticosteroids (e.g., prednisone, prednisolone), Anti-malarial agents (e.g., chloroquine, hydroxychloroquine), or Conventional immunosuppressants (e.g., mycophenolate mofetil, azathioprine, calcineurin inhibitors, methotrexate)

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