Live Geos: https://partners.subjectwell.com/publishers/geos_report/5efd3678-7298-4151-a193-9168cbedf995 *COPY AND CREATIVE MUST BE SUBMITTED TO [email protected] PRIOR TO GOING LIVE* Ages: 18+ Gender: All Study Description: The purpose of this study is to see whether an investigational drug can be used to treat depression that has not responded to other antidepressant therapies. Many people who receive antidepressant treatment for their depression do not get an adequate response to the medicines they are taking. If someone has taken, or is currently taking, two or more antidepressants that are not working, this is sometimes referred to as treatment-resistant depression or TRD. The investigational drug in this study is a synthetic (man-made) form of psilocybin, also known as 'magic mushrooms'. The use of this study drug is legal for research purposes. You may qualify to participate if you are currently experiencing a depressive episode that is not being helped with medication. If enrolled, you will be randomly selected to receive either the investigational study drug or a placebo with the support of a specially trained therapist. Placebo capsules will look like the investigational drug but will not contain any active ingredients. Twice the number of people will be selected to receive the investigational drug versus placebo. The dosing session will last approximately 6-8 hours and will be video and audio recorded. You will be required to attend several screening visits to determine your eligibility for the study. Your total participation in the study will last up to approximately 1 year with multiple follow-up appointments after your dosing session. There are up to two re-treatment opportunities throughout the study. One is an open label period of the study where you are guaranteed to receive the investigational study drug, if you are eligible. Please note, some of the visits during the study can be conducted remotely. Study assessments will include collections of blood and urine samples, physical exams, and questionnaires on your experience and mental health. The research site conducting the study will be able to provide you with more information about the requirements for enrollment. Reimbursement for reasonable, out-of-pocket expenses and travel may be available to qualified individuals. Qualifications: - Must currently be taking two or more anti-depression medications, but still experiencing depression - Cannot have a history of schizophrenia, schizoaffective disorder, bipolar, or borderline personality disorder

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